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The PTO s statements with respect to patenting of whole genes are consistent with established judicial precedent Although the issue of patenting genes that code for important proteins of known function is controversial but well settled from a legal standpoint, attempts to patent mere fragments of genes or smaller pieces of genetic material give rise to even more acrimonious debate and less legal certainty (Holman and Munzer, 2000) Most of this discussion has centered on ESTs and SNPs An EST, or expressed sequence tag, is a genetic sequence fragment that may be used as a probe to positively identify or tag a whole gene ESTs were used initially by Craig Venter and Mark Adams to identify many human genes (Davies, 2001).

Another pitfall of display ad measurement is the more recent development of view-through conversion tracking. The view-through tracking concept is supposed to work by registering when a visitor views an ad, but may not click on it, and later visits the site for the ad and performs a conversion action. When such a visit or conversion occurs, a view-through visit or conversion is reported, rewarding the display ad with a new level of perceived value. The problem with this form of measurement is that a view may not mean much. It presumes a relationship between viewing the ad and the visitor later going to the Web site, when there may well be little or no such relationship. Considering the case of the impression that doesn t count (that is, one that isn t actually seen by the visitor), it is entirely possible to reward display ads for view-through visits or conversions that the ad really had nothing to do with. Furthermore, view-through tracking relies on third-party browser-based or Flash-based cookies, which are prone to much higher deletion and blocking rates than rst-party cookies. Thus, a signi cant portion of those who view ads and later visit a Web site isn t likely to be counted. Overall, while the concept of view-through measurement is fantastic, the technology can be misleading when too great an emphasis is placed on it. View-through measurement should be used, but not as a primary metric for evaluating display and rich media advertising performance.

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There they sit, gathering dust in their random heaps, until a family member with a desire to do genealogical research (and plenty of spare time) finally comes along to make sense of the chaos Without including some systematic and meaningful ordering of content as application integration takes place, the knowledge held by the organization becomes, for all practical purposes, useless..

Their methods sought to shortcut the sequencing of those portions of the human genome that are most relevant to drug discovery those portions encoding proteins by tagging expressed regions for focus in further research With the tag, or EST sequence, in hand, elucidation of the entire coding gene would be facilitated An SNP, or single-nucleotide polymorphism, is a mere single base pair variation from the reference genetic sequence found in most members of a population SNPs are the most common points of departure between the genomes of individuals, which are, for all apparent differences among people, virtually identical (Davies, 2001) SNPs located within the coding regions of genes themselves may have a direct effect on the protein production that is biologically benign, or profoundly negative, such as in causing disease (Davies, 2001).

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SNPs may thus give rise to disease, increased susceptibility to disease, sensitivity or insensitivity to certain drug treatments, or adverse side effects from those treatments Alternatively, SNPs may mark the presence of disease-causing genes or indicate disease susceptibilities or drug sensitivities Scrutiny of inheritance patterns of SNPs in families af icted with genetic disorders has revealed links to previously unknown disease genes in close proximity to SNPs within af icted individuals genomes (Davies, 2001) In this way, SNPs can demarcate errant disease genes, thereby facilitating the tracking and identi cation of the disease genes themselves The study of these small genetic differences is thus critically important in understanding disease and its treatment A full understanding of the SNPs of various disease subpopulations provides the potential for individualization of drug treatment on the basis of genetics.

Equation (6.58) can be written in matrix format as a = aef A 1p Now substituting [A] from (6.55) we obtain a = aef ff 1p

Forced to seek counseling by the court, Ron was resistant from the very start, even though assured that confidentiality is an important part of the therapeutic relationship1 He postures himself defensively, crosses his arms tightly across his chest, taps his foot furiously in endless circles, and glares at the interviewer, never breaking eye contact An aggressive stance is firmly in place For almost a year now, Ron has refused to pay child support to his former wife Although he states openly that his position is deplorable, he nevertheless answers specific questions only reluctantly Sometimes, he challenges the therapist by asking, Why would you need to know that I just don t see the relevance Otherwise, he deflects questions or gives only marginally useful information.

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