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blink of an eye. Within a few million years, nearly all the dinosaurs were gone. However, the small rodents survived because they had the ability to generate internal body heat. In addition, they possessed a characteristic that might best be called wiliness a brain that could figure out how to deal with unusual or complicated situations and crises. Adversity plays an important role in the evolution of intelligent life. Without problems, there is no need for reasoning power. If the environment becomes ideal and stays that way, evolutionary progress comes to a halt. The dinosaurs are an example of a species that lived in harmony with the environment and adjusted to a status quo that would, were it not for the sudden cooling of Earth 65 million years ago, still exist today. We can curse our cold winters, but we owe our existence to them, according to the most popular theories of evolution and natural selection.

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Relay site codes: ae-United Arab Emirates, al-Albania, an-Antigua, ar-Armenia, as-Ascension, au-Austria, bo-Bonaire Neth. Antilles, bu-Bulgaria, ca-Sackville Canada, ch-China, cl-Chile, cu-Cuba, cy-Cyprus, de-Delano USA, fg-French Guiana, fr-France, ga-Gabon, ge-Germany, gr-Greenville USA, it-Italy, ja-Japan, ka-Kazakhstan, ko-South Korea, la-Latvia, li-Lithuania, ma-Madagascar, ml-Mali, mo-Moldova, ne-Netherlands, om-Oman, po-Sines Portugal, ru-Russia, rw-Rwanda, sc-Cypress Creek SC, se-Seychelles, si-Singapore, sl-Sri Lanka, so-Slovakia, sp-Spain, sw-Sweden, ta-Taiwan, th-Thailand, uk-United Kingdom, uz-Uzbekistan, wb-WBCQ USA, wr-WRMI USA, wy-WYFR USA, za-South Africa. Notes Days of week: Su-Sunday, M-Monday, Tu-Tuesday, W-Wednesday, Th-Thursday, F-Friday, Sa-Saturday, exW-except Wednesday. Target areas: Af-Africa, Am-America, As-Asia, Eu-Europe, LA-Latin America, ME-Middle East, NA-North America, Oc-Oceania/Australia; Other: alt-alternate frequency, drm-Digital Radio Mondiale, occ-occasional use, se-Special English. Courtesy of Daniel Sampson; www.primetimeshortwave.com

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Glycolipids are derived from sphingosine, but have a sugar unit, such as glucose or galactose attached instead of the choline unit. The carbohydrate can be extended to form more complex structures, including branches. The sugars point out from the cell surface and are involved in cell-cell recognition. Cholesterol is an essential component of mammalian membranes. It is obtained from the diet or can be synthesized from acetyl-CoA.

Part II:

levels) and an evaluation for cancer are also in order in obscure cases It must be remembered that chronic intoxication with alcohol, barbiturates, or other sedative drugs, some of which are given to suppress nervousness or insomnia, may contribute to fatigability The rapid and recent onset of fatigue should always suggest the presence of an infection, a disturbance in uid balance, gastrointestinal bleeding, or rapidly developing circulatory failure of either peripheral or cardiac origin The features that suggest sleep apnea have been mentioned above and are discussed further on page 344 Finally, it bears repeating that lassitude and fatigue must always be distinguished from genuine weakness of muscle.

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The demonstration of reduced muscular power, re ex changes, fasciculations, and atrophy sets the case analysis along different lines, bringing up for particular consideration diseases of the peripheral nervous system or of the musculature Rare, dif cult-to-diagnose diseases that cause inexplicable muscle weakness and exercise intolerance are masked hyperthyroidism, hyperparathyroidism, ossifying hemangiomas with hypophosphatemia, some of the kalemic periodic paralyses, hyperinsulinism, disorders of carbohydrate and lipid metabolism, the mitochondrial myopathies, and possibly adenylate deaminase de ciency Treatment It is our impression that most such patients who have not had a clear preceding febrile viral infection or one of the medical illnesses associated with fatigue from the outset are depressed They are best treated with gradually increasing exercises and antidepressant medication, although this regimen is not always successful.

There are reports of success in treating these patients with mineralocorticoids (predicated on the above-mentioned orthostatic intolerance), estradiol patches, hypnosis, and a variety of other medical and nonmedical treatments Cognitive and behavioral therapies have the most consistent record of success The numerous trials relating to treatment of chronic fatigue syndrome are carefully summarized in the Effective Health Care Report from the National Health Service Centre for Reviews and Dissemination, which comes to no rm conclusions A very few patients exhibit the special psychologic disorder related to litigation (compensation neurosis) Noteworthy is the frequency with which a similar syndrome has become the basis of court action against employers, as in the sick-building syndrome, or claims against the government Attribution to Lyme disease should be resisted without rm evidence of a clinical infection..

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